Gloved hand holding a stack of petri dishes with bacterial cultures, set on a clean laboratory surface

Colic

Extensive clinical studies have proven Bio- Gaia Drops containing Limosilactobacillus reuteri Protectis® /TM to be totally safe for babies, from the very first day of life.

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Baby Colic

They have also been proven to be a highly effective treatment for baby colic, significantly reducing average daily crying time and even show a prophylactic effect.

The first such study, published in the medical journal Pediatrics (2007 ), showed that after 28 days of treatment with BioGaia® Drops average crying time for colicky babies had decreased from 159 minutes to only 51 minutes, and that fully 95% of babies in the study showed marked improvements in crying time. In 2012 another study also published in the journal of Pediatrics showed a decrease in crying time of 56%! BioGaia® Drops contributed not only to babies' comfort and happiness, but also to the harmony of the entire family.

It’s possible to prevent colic in healthy infants

A just released study of 468 healthy newborns shows that infants given the probiotic BioGaia® (Limosilactobacillus reuteri Protectis® /TM) cried less than half as long as infants given a placebo. The infants given BioGaia® drops also had significantly fewer daily regurgitations and were less constipated compared to infants in the placebo group. As a result, the use of BioGaia® drops proved to be cost saving for both parents and the community. Get an overview of all studies with BioGaia® (Limosilactobacillus reuteri Protectis®) proven effective for colicky babies.

BioGaia® Probiotic Drops

Containing Limosilactobacillus reuteri Protectis®, BioGaia® Pobiotic Drops promote the growth of good bacteria in the infant’s intestinal tract, re-establishing a healthy bacterial balance and thus significantly reduce the average daily crying time and even show a prophylactic effect in avoiding colic, constipation and regurgitation.

BioGaia® Dosage recommendations for colic

drops daily for at least 4 weeks – or ideally from the first day of life!

Prospective Randomized Study

Limosilactobacillus reuteri ATCC 55730 versus Simethicone in the Treatment of Infantile Colic

Savino, Pelle, Oggero. J Pediatr 2007;119:e124-e130

 

Conclusions

  • The intake of BioGaia® (L.reuteri) resulted in significantly less crying time within one week of treatment, compared to standard therapy in these infants. This effect was even more pronounced at the end of the 4-weeks study.
  • No side-effects were observed in either group.

Facts

  • Prospective, randomized, double blind, study against Simethicon
  • 90 breastfed colicky infants aged 11-80 days
  • Five drops per day of BioGaia® (Limosilactobacillus reuteri )(n=40) or simethicone (n=40) 60 mg/day for 21 days

Randomized, Double-Blind, Placebo-Controlled Trial

Limosilactobacillus reuteri DSM 17938 for the Management of Inf antile Colic in Breastfed Infants.

Szajewska, Gyrczuk, Horvath. J Pediatr 2013;162:257-262.
Significant improved family quality of life with BioGaia®.

Conclusions

  • All outcome measures significantly improved throughout intervention and maintained during follow-up.
  • Highly significant improvements in parents/ family quality of life with L. reuteri Protectis®.
  • The proof of the effectiveness of L. reuteri Protectis® in colic is again confirmed and now very strong.

Facts

  • Randomized, double blind, placebo-controlled study
  • 80 exclusively or predominately breastfed colicky infants
  • Five drops per day of BioGaia® (Limosilactobacillus reuteri Protectis®) (n=40) or placebo (n=40) for 21 days

Clinical and Socio-Economic Impact

Act and not React: Prophylactic use of a Probiotic in the Prevention of Colic, Regurgitation and Functional Constipation.

Indrio et al. JAMA Pediatr. JAMA Pediatr.
Published online January 13, 2014. doi:10.1001/jamapediatrics.2013.4367

Results

Less, crying, less regurgitation, less constipation…

  • with BioGaia® (L. reuteri Protectis®)
  • Mean duration in crying time: 38 vs 71 minutes
  • Mean number of regurgitations per day: 2.9 vs 4.6
  • Mean number of evacuations per day: 4.2 vs 2.6
  • Means less costs for parents: Mean savings per patient: Euro 88

Conclusions

  • Prophylactic use of BioGaia® (L.reuteri Protectis®) during the first 3 months of life reduced the onset of functional gastrointestinal disorders and reduced private and public costs for the management of this condition.

Facts

The study was a placebo-controlled, double blind, multicentre trial performed in nine neonatology units in Italy. 589 patients were randomly allocated to receive 1x108cfu of the probiotic Limosilactobacillus reuteri Protectis® (BioGaia® drops) or placebo daily for 90 days. Of these 468 infants completed study, 238 in the Limosilactobacillus reuteri Protectis® group and 230 in the placebo group. All included infants were healthy at study start.